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KMID : 0363320070280020262
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 2 p.262 ~ p.274
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The Association of Interleukin-1 Receptor Antagonist and Peroxisome Proliferator-Activated Receptor-{gamma}2 Pro12Ala Polymorphism with Ischemic Stroke in Type 2 Diabetes Mellitus Patients
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Jang Won-Man
Lee Byung-Cheol
Ahn Se-Young
Doo Ho-Kyung
Ahn Young-Min
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Abstract
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Objective : It has been reported that two-repeats (IL1RN {ast}2) of interleukin-1 receptor antagonist (IL-1Ra) gene is associated with ischemic stroke, and that Ala allele of the common Pro12Ala polymorphism in PPAR-{gamma}2 isoform is associated with reduced risk for type 2 DM and its complications. The aim of the present study is to assess the association of IL-1Ra and PPAR-{gamma}2 Pro12Ala polymorphism with the presence of ischemic stroke in the case of diabetic and non-diabetic patients.
Methods : Genomic DNA was obtained from 373 healthy subjects, 157 DM subjects without ischemic stroke (known DM duration {ge}10 years) and 302 ischemic stroke patients (including with DM). IL-1Ra polymorphism was analysed by polymerase chain reaction (PCR), and PPAR-{gamma}2 polymorphism by restriction fragment length polymorphism after PCR.
Results : IL1RN {ast}1/IL1RN {ast}2 genotype was associated with significantly increased risk for DM (OR=2.86, P = 0.0008) and ischemic stroke (OR=2.74, P = 0.0016). Pro/Ala genotype was associated with the reduced risk for DM (OR=0.53, P = 0.0491) and ischemic stroke (OR=0.38, P = 0.0039). They were also associated with the reduced risk for ischemic stroke in the DM patients compared with DM without ischemic stroke (OR=0.25, P = 0.0321).
Conclusions : IL1RN {ast}2 allele could be an accelerating factor, not a predictive marker for ischemic stroke in type 2 DM. The Pro/Ala genotype of PPAR-{gamma}2 Pro12Ala polymorphism may be associated with reduced risk for ischemic stroke with type 2 DM. Therefore it could be a useful predictive marker for ischemic stroke in Korean type 2 DM.
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KEYWORD
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ischemic stroke, type 2 diabetes mellitus, Interleukin-1 receptor antagonist, peroxisome proliferator-activated receptor-{gamma}2, polymorphism
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